These medications are anticholinesterase drugs and are administered either orally or via injection. Many chronic diseases commonly cause muscle weakness. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. These chemicals lead to feelings of tiredness or fatigue. But it also may cause some of the same muscle problems as the pharmaceutical products. Your healthcare provider will ask when your signs and symptoms started and what makes your weakness worse. Commonly prescribed antipsychotics include aripiprazole (Abilify), haloperidol (Haldol), olanzapine (Zyprexa), risperidone (Risperdal) and ziprasidone (Geodon). Less commonly-used medicines which can cause muscle weakness and damage to muscles include: Prolonged use of alcohol can cause weakness of shoulder and hip muscles. Long-term effects also may include muscle weakness. It can progress to permanent changes if the medicines are not stopped. A natural benefit: Omega-3 fatty acids are also thought to be natural fatigue fighters. However, exercise is still beneficial and it is still possible to increase muscle power and strength with a careful and safe exercise routine. How they can cause fatigue: Diuretics can interfere with the balance of electrolytes —including sodium, potassium and chloride — in your body. Patients often show signs of depression and poor sleep. The muscle isn't genuinely weaker, it can still do its job but it takes you more effort to manage it. Alternatives: Talk with your doctor or other health care provider about switching to another type of blood pressure medication. What you need to know about post-viral fatigue. In any muscle injury, bleeding from damaged muscle fibres occurs inside the muscle, followed by swelling and inflammation. The weakness affects only the muscles served by the irritated or compressed nerve. Antidepressants, antipsychotics and benzodiazepines can cause drowsiness, notes MayoClinic.com. More than 20 million Americans take prescription PPIs, including esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec) and pantoprazole (Protonix), some of which are available over the counter. It's one of the reasons doctors try to avoid putting patients on long-term steroids if possible. You are leaving AARP.org and going to the website of our trusted provider. If you need to discontinue a PPI, you must do it very slowly. The term myasthenia is from my- from Greek μυο meaning "muscle" + -asthenia ἀσθένεια meaning " weakness ". Even though recovery is usual, if inflammation is severe (such as a bad bout of influenza), the weakness can last quite a while. In the physical examination, the doctor should objectively note down your loss of strength, conduct a neurological survey and search for patterns of weakness and other abnormalities. Diseases of the neuromuscular system, injuries, metabolic diseases, and toxins can all cause of measurable muscle weakness. Interferon - used in some cancers and for multiple sclerosis (MS). They’re also used to treat or prevent infections that can complicate surgery or other medical procedures. In untreated hypothyroidism, muscle degeneration and wasting can develop. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Inflammatory diseases of muscle typically affect older adults and include conditions such as polymyalgia rheumatica (muscles of the shoulders and thighs become tender and weak), polymyositis and dermatomyositis. Any illness with generalised temperature and muscle inflammation can be the trigger. This leads to easy tiring when you try to do things that would have been easier when the muscles were fit. Heart Drugs This can be so extreme that patients can't keep their eyelids lifted and speech can become slurred. When you feel them they may be floppy and a little reduced in bulk. Chronic fatigue has many causes, including illnesses such as anemia and multiple sclerosis as well as depression and other psychiatric disorders. Muscle wasting will eventually occur: muscles become less chunky and more floppy. The blood supply to the muscles is slowed and this becomes particularly noticeable with exercise, as it can't keep up with the demand. Moreover, bipolar medications such as benzodiazepines may also negatively affect balance and muscle control. Any advice or information provided should not be followed in lieu of a personal consultation with a trained medical professional. This can result in symptoms like weakness, amnesia, nerve pain and symptoms of heart failure. Other rare hormonal causes of muscle weakness include acromegaly (excessive levels of a hormone called growth hormone), underactivity of the pituitary gland (hypopituitarism) and severe vitamin D deficiency. Once your doctor has talked to you about your symptoms, they will be able to offer some guidance as to the likely cause. Some antihistamines are also used to prevent motion sickness, nausea and vomiting, and to treat anxiety or insomnia. You can also progress from one to another. Some muscle tiredness is mainly muscle 'fatigability' - the muscle starts off normally but tires very quickly and takes longer to recover than normal. Why they’re prescribed: Diuretics (sometimes called water pills) are used to treat high blood pressure, glaucoma, edema and other conditions. Other rare causes: direct damage to muscles can occur in rare inherited metabolic conditions. Examples of medications that can cause muscle weakness include: amiodarone (Cordarone) antithyroid medications, such as methimazole (Tapazole) or propylthiouracil Hypothyroidism is a common condition but it is usually picked up early and treated before long-lasting muscle problems can result. Antipsychotics also are often prescribed “off label” to treat agitation and depression, among other conditions. Unfortunately, as explained above, steroids also cause muscle wasting and weakness. You might also want to explore switching drugs, especially if you’re older and taking one of the tricyclic antidepressants, which are considered to be potentially inappropriate drugs for older people. Similarly, the package insert for cephalexin (Keflex, Keftabs, Panixine, Biocef, Zartan) lists fatigue as a potential side effect. They will then need to test your nerves to see whether the muscles are getting the right signals to act. What to do about lumps on the vagina or vulva, The truth about getting pregnant after 40. The disease can be very difficult to spot and special tests are needed to confirm it. To get the best treatment, come in to Complete Care Health Centers and see one of our providers today. These inflammatory myopathies can occur in autoimmune disorders where the immune system attacks itself, and also from infectious causes such as bacteria, viruses, and fungi. Muscles require a fast supply of oxygen from the blood, particularly when exercising. Causes for leg weakness range in severity, so it's important to pay attention to your symptoms and talk to your doctor. In studies, the side effects include fatigue, lethargy and weakness. Most forms of MND begin at the outer extremities, hands and feet and gradually move inwards. Botulism, a rare and serious illness caused by Clostridium botulinum bacteria, can also lead to muscle weakness. by Dr. Armon B. Neel Jr. If you still have severe reflux problems, you and your doctor may want to consider the use of an H2 blocker such as ranitidine (75 mg every 12 hours as needed). In addition, as diabetes progresses, the blood supply to small nerves is lost. 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